Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer

Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer

Following the consensus definition of cancer cachexia, more studies are using CT scan analysis of truncal muscles as a marker of muscle wasting. However, how CT-derived body composition relates to function, strength and power in patients with cancer is largely unknown. We aimed to describe the relat...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2019-12, Vol.38 (6), p.2875-2880
Main Authors: MacDonald, A.J., Miller, J., Ramage, M.I., Greig, C., Stephens, N.A., Jacobi, C., Preston, T., Fearon, K.C.H., Skipworth, R.J.E.
Format: Article
Language:eng
Subjects:
Function
MRI
Quadriceps
Truncal muscle
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Summary:Following the consensus definition of cancer cachexia, more studies are using CT scan analysis of truncal muscles as a marker of muscle wasting. However, how CT-derived body composition relates to function, strength and power in patients with cancer is largely unknown. We aimed to describe the relationship between CT truncal (L3) skeletal muscle index (SMI) and MRI quadriceps cross sectional area with lower limb strength, power and measures of complex function. Patients undergoing assessment for potentially curative surgery for oesophagogastric or pancreatic cancer were recruited from the regional upper gastrointestinal (UGI) or hepatopancreaticobiliary (HPB) multi-disciplinary team meetings. Maximum Isometric Knee Extensor Strength (IKES) and Maximum Leg Extensor Power (Nottingham Power Rig) (LEP) were used as measures of lower limb performance. Both Sit to Stand (STS) and Timed Up and Go (TUG) were used as measures of global complex muscle function. Muscle SMI was measured from routine CT scans at the level of the third lumbar vertebrae (L3) and MRI scan was used for the assessment of quadriceps muscles. Linear regression analysis was performed for CT SMI or MRI quadriceps as a predictor of each measure of performance. Forty-four patients underwent assessment. Height and weight were significantly related to function in terms of quadriceps power, while only weight was associated with strength (P 
ISSN:0261-5614
1532-1983