Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model

As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algor...

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Published in:Human brain mapping 1999, Vol.8 (4), p.235-244
Main Authors: Bloom, Alan S., Hoffmann, Raymond G., Fuller, Scott A., Pankiewicz, John, Harsch, Harold H., Stein, Elliot A.
Format: Article
Language:English
Subjects:
Adult
Algorithms
brain
Brain - drug effects
Brain - physiology
clustering
Computer Simulation
Humans
Image Processing, Computer-Assisted
Injections, Intravenous
Magnetic Resonance Imaging
Models, Neurological
nicotine
Nicotine - administration & dosage
Nicotine - pharmacokinetics
Nicotine - pharmacology
pharmacology
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container_end_page 244
container_issue 4
container_start_page 235
container_title Human brain mapping
container_volume 8
creator Bloom, Alan S.
Hoffmann, Raymond G.
Fuller, Scott A.
Pankiewicz, John
Harsch, Harold H.
Stein, Elliot A.
description As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algorithm for the detection and analysis of brain activation patterns following acute drug administration using fMRI are presented. A waveform analysis protocol (WAP) input function has been developed that is based upon the single‐dose pharmacokinetics of a drug of interest. As a result of this analysis, regional brain activation can be characterized by its localization and intensity of activation, onset of action, time to peak effect, and duration of action. A global statistical test for significant drug effects based upon the probability of a voxel being activated by a saline vehicle injection is applied to grouped data on a voxel by voxel basis. Representative data are presented using nicotine as a prototypical agent. Using this method, statistically significant drug‐induced brain activation has been identified in several key cortical and subcortical brain regions. Hum Brain Mapping 8:235–244, 1999. © 1999 Wiley‐Liss, Inc.
doi_str_mv 10.1002/(SICI)1097-0193(1999)8:4<235::AID-HBM7>3.0.CO;2-3
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source Wiley-Blackwell Journals; PubMed Central
subjects Adult
Algorithms
brain
Brain - drug effects
Brain - physiology
clustering
Computer Simulation
Humans
Image Processing, Computer-Assisted
Injections, Intravenous
Magnetic Resonance Imaging
Models, Neurological
nicotine
Nicotine - administration & dosage
Nicotine - pharmacokinetics
Nicotine - pharmacology
pharmacology
title Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model
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