Determination of drug-induced changes in functional MRI signal using a pharmacokinetic model

As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algor...

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Bibliographic Details
Published in:Human brain mapping 1999, Vol.8 (4), p.235-244
Main Authors: Bloom, Alan S., Hoffmann, Raymond G., Fuller, Scott A., Pankiewicz, John, Harsch, Harold H., Stein, Elliot A.
Format: Article
Language:English
Subjects:
Adult
Algorithms
brain
Brain - drug effects
Brain - physiology
clustering
Computer Simulation
Humans
Image Processing, Computer-Assisted
Injections, Intravenous
Magnetic Resonance Imaging
Models, Neurological
nicotine
Nicotine - administration & dosage
Nicotine - pharmacokinetics
Nicotine - pharmacology
pharmacology
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Summary:As the applications of functional magnetic resonance imaging (fMRI) expand, there is a need for the development of new strategies for data extraction and analysis that do not require the presentation of stimuli in a repeated on/off pattern. A description and evaluation of a method and computer algorithm for the detection and analysis of brain activation patterns following acute drug administration using fMRI are presented. A waveform analysis protocol (WAP) input function has been developed that is based upon the single‐dose pharmacokinetics of a drug of interest. As a result of this analysis, regional brain activation can be characterized by its localization and intensity of activation, onset of action, time to peak effect, and duration of action. A global statistical test for significant drug effects based upon the probability of a voxel being activated by a saline vehicle injection is applied to grouped data on a voxel by voxel basis. Representative data are presented using nicotine as a prototypical agent. Using this method, statistically significant drug‐induced brain activation has been identified in several key cortical and subcortical brain regions. Hum Brain Mapping 8:235–244, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:1065-9471
1097-0193
DOI:10.1002/(SICI)1097-0193(1999)8:4<235::AID-HBM7>3.0.CO;2-3