Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial

Objective To investigate the clinical efficacy of a multi‐strain probiotic product on bowel habits and microbial profile in participants with functional constipation. Methods This was a randomized, double‐blind, placebo‐controlled and parallel‐arm study. Altogether 94 otherwise healthy adults aged 1...

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Bibliographic Details
Published in:Journal of digestive diseases 2019-09, Vol.20 (9), p.435-446
Main Authors: Martoni, Christopher J., Evans, Malkanthi, Chow, Cheryl‐Emiliane T., Chan, Luisa S., Leyer, Gregory
Format: Article
Language:English
Subjects:
Abundance
Adolescent
Adult
Aged
Bacterial Typing Techniques
bowel habit
Constipation
Constipation - microbiology
Constipation - physiopathology
Constipation - therapy
Defecation - physiology
Double-Blind Method
Energy Intake - physiology
Exercise - physiology
Feces - microbiology
functional constipation
Gastrointestinal Microbiome - physiology
Humans
Intestine
Metagenome - physiology
microbiome
Microbiota
Middle Aged
Original
ORIGINAL ARTICLES
probiotic
Probiotics
Probiotics - adverse effects
Probiotics - therapeutic use
Prospective Studies
Psychometrics
Quality of Life
randomized controlled trial
Treatment Outcome
Yogurt
Young Adult
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Summary:Objective To investigate the clinical efficacy of a multi‐strain probiotic product on bowel habits and microbial profile in participants with functional constipation. Methods This was a randomized, double‐blind, placebo‐controlled and parallel‐arm study. Altogether 94 otherwise healthy adults aged 18 to 65 years with symptoms of functional constipation were randomized as part of the intention‐to‐treat population. The participants received a placebo or the probiotic product (1.5 × 1010 CFU/day), consisting of Lactobacillus acidophilus DDS‐1, Bifidobacterium animalis subsp. lactis UABla‐12, Bifidobacterium longum UABl‐14 and Bifidobacterium bifidum UABb‐10 over 4 weeks. Outcomes included the patient assessment of constipation‐symptom (PAC‐SYM) questionnaire, stool frequency and consistency, and microbial profile. Results There were no significant between‐group differences in the PAC‐SYM score, despite significant within‐group differences (P 
ISSN:1751-2972
1751-2980
DOI:10.1111/1751-2980.12797