G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans

There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overw...

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Published in:Curēus (Palo Alto, CA) CA), 2019-09, Vol.11 (9), p.e5776
Main Authors: Rodríguez-Rodríguez, Ismael, Fernández-Quiroga, Karla A, Araujo-Moreno, Pedro, Balderas-Rentería, Isaías, Gonzalez-Santiago, Omar
Format: Article
Language:English
Subjects:
Age
Cholesterol
Endocrinology/Diabetes/Metabolism
Females
Genetics
Genotype & phenotype
Lipids
Lipoproteins
Males
Metabolic disorders
Metabolic syndrome
Obesity
Overweight
Polymorphism
Public Health
Science
Triglycerides
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Summary:There is extensive evidence to believe that the endocannabinoid system plays an important role in energy homeostasis through a variety of mechanisms. This study aimed to analyze the association between polymorphism rs12720071 of the cannabinoid type 1 receptor (CNR1) gene with dyslipidemia and overweight in young, healthy Mexicans. The association was analyzed with a logistic regression model and expressed as odds ratio (OR). A total of 148 individuals agreed to participate. Overall, the serum concentrations of lipids were found to be in the normal range. However, females presented higher levels of cholesterol and low-density lipoprotein (LDL) than males [probability value (p) = 25) [OR = 3.57; 95% confidence interval (CI): 1.05-12.20; p = 0.04], than males. Our results suggest that this polymorphism could influence BMI in young females.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.5776