Comparison of the Kansas City Cardiomyopathy Questionnaire and Minnesota Living With Heart Failure Questionnaire in Predicting Heart Failure Outcomes

Patient-reported outcome measures (PROMs) are relevant independent outcomes in heart failure (HF) care and are predictive of subsequent hospitalization and death in HF. The Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Minnesota Living with Heart Failure Questionnaire (MLHFQ) are the 2 mos...

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Bibliographic Details
Published in:The American journal of cardiology 2019-03, Vol.123 (5), p.807-812
Main Authors: Yee, Derek, Novak, Eric, Platts, Anne, Nassif, Michael E., LaRue, Shane J., Vader, Justin M.
Format: Article
Language:English
Subjects:
Angioplasty
Cardiomyopathies - complications
Cardiomyopathies - mortality
Cardiomyopathies - therapy
Cardiomyopathy
Clinical outcomes
Congestive heart failure
Death
Diabetes
Discrimination
Female
Health Status
Heart failure
Heart Failure - etiology
Heart Failure - mortality
Heart Failure - therapy
Heart rate
Hospitalization - trends
Humans
Hypertension
Implantation
Kansas - epidemiology
Male
Medical prognosis
Middle Aged
Minnesota - epidemiology
Mortality
Patient Reported Outcome Measures
Patients
Prognosis
Prospective Studies
Quality of life
Questionnaires
Reclassification
Registries
Stroke
Surveys and Questionnaires
Survival Rate - trends
Transplants & implants
Variables
Ventricle
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Summary:Patient-reported outcome measures (PROMs) are relevant independent outcomes in heart failure (HF) care and are predictive of subsequent hospitalization and death in HF. The Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Minnesota Living with Heart Failure Questionnaire (MLHFQ) are the 2 most widely adopted PROMs specific to HF. We compared their prognostic abilities in a prospective cohort of HF patients. A prospective cohort of subjects from a single-center registry was analyzed with regard to baseline KCCQ and MLHFQ scores and the outcomes of death, transplant, or left ventricular assist device implantation and hospitalization. A total of 516 subjects with reduced left ventricular ejection fraction (HFrEF) and 151 subjects with preserved left ventricular ejection fraction (HFpEF) were included. Discrimination was assessed using c-statistics based on time-to-event analyses and receiver-operator curves. The additive contribution of MLHFQ was assessed through the change in c-statistic, incremental discrimination index, and category-free net reclassification index. Overall, KCCQ was superior to MLHFQ for predicting death/transplant/ventricular assist device (c-statistic 0.702 [0.666 to 0.738] and 0.658 [0.621 to 0.695] respectively, p value for difference
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2018.11.037