Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruite...

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Bibliographic Details

Published in:	Scientific reports 2019-10, Vol.9 (1), p.14940-9, Article 14940
Main Authors:	Rivera-Correa, Juan, Conroy, Andrea L, Opoka, Robert O, Batte, Anthony, Namazzi, Ruth, Ouma, Benson, Bangirana, Paul, Idro, Richard, Schwaderer, Andrew L, John, Chandy C, Rodriguez, Ana
Format:	Article
Language:	eng
Subjects:	Acute Kidney Injury - blood Acute Kidney Injury - epidemiology Acute Kidney Injury - immunology Anemia Anemia - blood Anemia - epidemiology Anemia - immunology Anti-DNA antibodies Antigens Autoantibodies Autoantibodies - blood Autoantibodies - immunology Autoantigens - immunology Autoimmune diseases Child Child, Preschool Children Deoxyribonucleic acid DNA DNA - immunology Female Follow-Up Studies Hemoglobin Humans Immunoglobulins Infant Kidneys Malaria Malaria, Falciparum - complications Malaria, Falciparum - immunology Malaria, Falciparum - mortality Male Morbidity Mortality Patient Discharge Patient Readmission - statistics & numerical data Phosphatidylserine Phosphatidylserines - immunology Plasmodium falciparum - immunology Prospective Studies Risk Assessment - methods Risk Assessment - statistics & numerical data Severity of Illness Index Uganda - epidemiology
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