Marital status is an independent prognostic factor in inflammatory breast cancer patients: an analysis of the surveillance, epidemiology, and end results database

Objectives The aim of this analysis was to study the impact of marital status on inflammatory breast cancer (IBC) patients, as the prognostic impact is yet to be studied in detail. Methods Data of IBC patients from 2004 to 2010 were sorted out from the database of surveillance, epidemiology, and end...

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Bibliographic Details
Published in:Breast cancer research and treatment 2019-11, Vol.178 (2), p.379-388
Main Authors: Liu, Yan-ling, Wang, Dun-wei, Yang, Zhu-chun, Ma, Rui, Li, Zhong, Suo, Wei, Zhao, Zhuang, Li, Zhi-wen
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Animals
Breast cancer
Cancer research
Chemotherapy
Clinical Trial
Databases, Factual
Development and progression
Disease Models, Animal
Disease Susceptibility
Epidemiology
Female
Humans
Inflammation
Inflammatory Breast Neoplasms - diagnosis
Inflammatory Breast Neoplasms - epidemiology
Inflammatory Breast Neoplasms - mortality
Inflammatory Breast Neoplasms - therapy
Kaplan-Meier Estimate
Marital Status
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Neoplasm Grading
Neoplasm Staging
Oncology
Population Surveillance
Prognosis
Proportional Hazards Models
Radiation therapy
Risk Assessment
Risk Factors
SEER Program
Surgery
Surveillance
Survival
Survival analysis
Young Adult
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Summary:Objectives The aim of this analysis was to study the impact of marital status on inflammatory breast cancer (IBC) patients, as the prognostic impact is yet to be studied in detail. Methods Data of IBC patients from 2004 to 2010 were sorted out from the database of surveillance, epidemiology, and end results (SEER), and overall survival (OS) rates and breast cancer-specific survival (CSS) rates were compared between a group of married and unmarried patients. The comparison was performed by Kaplan–Meier method with log-rank test, and multivariate survival analysis of CSS and OS was performed using the Cox proportional hazard model. Results Data of 1342 patients were collected from the SEER database, on an average 52% of married patients ( n  = 698, 52.01%) and 48% of unmarried patients ( n  = 644, 47.99%) for this analysis. Married patients were more likely to be more younger (aged ≤ 56) (52.44% vs. 43.94%), white ethnicity (83.24% vs. 71.58%), HoR positive (48.28% vs. 41.61%), more patients received surgery (78.51% vs. 64.60%), chemotherapy (90.69% vs. 80.12%) and radiotherapy (53.44% vs. 44.41%) compared to unmarried group, and less likely to be AJCC stage IV (26.22% vs. 35.40%) (All P ˂ 0.05). Married patients had better 5-year CSS (74.90% vs. 65.55%, P 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-019-05385-8