Molecular epidemiology and clinical characteristics of norovirus gastroenteritis with seizures in children in Taiwan, 2006–2015

Abstract This study examined the characteristics of norovirus (NoV) gastroenteritis associated with convulsions in children and its molecular epidemiology. From July 2006 through December 2015, NoV infection was confirmed by the genome detection using reverse transcriptase polymerase chain reaction....

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-10, Vol.98 (40), p.e17269-e17269
Main Authors: Chen, Ying Fang Elaine, Wang, Chuan Yu, Chiu, Cheng Hsun, Kong, Shu Sing, Chang, Yi Jung, Chen, Shih Yen
Format: Article
Language:English
Subjects:
Observational Study
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Summary:Abstract This study examined the characteristics of norovirus (NoV) gastroenteritis associated with convulsions in children and its molecular epidemiology. From July 2006 through December 2015, NoV infection was confirmed by the genome detection using reverse transcriptase polymerase chain reaction. Viral genotyping with strain validation was achieved using sequence analyses with Basic Local Alignment Search Tool genome identification. The patients’ clinical features were assessed retrospectively, focusing on convulsive disorders. The diagnosis of encephalitis followed the International Encephalitis Consortium. Seizures occurred in 52 (20.9%) of 249 NoV infections. GII.4 Den_Haag_2006b (n = 22, 42.3%) and GII.4 Sydney 2012 (n = 10, 19.2%) were major variants correlated with convulsions. Patient with convulsions tend to have GII.4 genotype infection ( P  
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000017269