Therapeutic hypothermia promotes cerebral blood flow recovery and brain homeostasis after resuscitation from cardiac arrest in a rat model

Laboratory and clinical studies have demonstrated that therapeutic hypothermia (TH), when applied as soon as possible after resuscitation from cardiac arrest (CA), results in better neurological outcome. This study tested the hypothesis that TH would promote cerebral blood flow (CBF) restoration and...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2019-10, Vol.39 (10), p.1961-1973
Main Authors: Wang, Qihong, Miao, Peng, Modi, Hiren R, Garikapati, Sahithi, Koehler, Raymond C, Thakor, Nitish V
Format: Article
Language:English
Subjects:
Animals
Arterial Pressure
Brain - blood supply
Brain - physiopathology
Cardiopulmonary Resuscitation - methods
Cerebrovascular Circulation
Heart Arrest - physiopathology
Heart Arrest - therapy
Homeostasis
Hypothermia, Induced - methods
Male
Original
Rats, Wistar
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Summary:Laboratory and clinical studies have demonstrated that therapeutic hypothermia (TH), when applied as soon as possible after resuscitation from cardiac arrest (CA), results in better neurological outcome. This study tested the hypothesis that TH would promote cerebral blood flow (CBF) restoration and its maintenance after return of spontaneous circulation (ROSC) from CA. Twelve Wistar rats resuscitated from 7-min asphyxial CA were randomized into two groups: hypothermia group (7 H, n = 6), treated with mild TH (33–34℃) immediately after ROSC and normothermia group (7 N, n = 6,37.0 ± 0.5℃). Multiple parameters including mean arterial pressure, CBF, electroencephalogram (EEG) were recorded. The neurological outcomes were evaluated using electrophysiological (information quantity, IQ, of EEG) methods and a comprehensive behavior examination (neurological deficit score, NDS). TH consistently promoted better CBF restoration approaching the baseline levels in the 7 H group as compared with the 7 N group. CBF during the first 5–30 min post ROSC of the two groups was 7 H:90.5% ± 3.4% versus 7 N:76.7% ± 3.5% (P 
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X18773702