Nitric Oxide Therapy for Diabetic Wound Healing

Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This pro...

Full description

Saved in:
Bibliographic Details
Published in:Advanced healthcare materials 2019-06, Vol.8 (12), p.e1801210-n/a
Main Authors: Malone‐Povolny, Maggie J., Maloney, Sara E., Schoenfisch, Mark H.
Format: Article
Language:English
Subjects:
Chemical compounds
chronic wounds
diabetes
Diabetes mellitus
Nitric oxide
Pharmacology
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This progress report examines the efficacy of a variety of NO‐based methods to improve wound outcomes, with particular attention given to diabetes‐associated chronic wounds. Nitric oxide (NO)‐based therapies for chronic wound healing are explored in this progress report. The use of NO to accelerate wound healing is motivated by its role as an endogenous regulator of inflammation and antibacterial agent. A number of NO‐based wound healing strategies are developed, including those that liberate NO from endogenous reservoirs and those that dose exogenous NO.
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.201801210