A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent s...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of experimental medicine 2019-09, Vol.216 (9), p.1999-2009
Main Authors:	Rana, Batika M J, Jou, Eric, Barlow, Jillian L, Rodriguez-Rodriguez, Noe, Walker, Jennifer A, Knox, Claire, Jolin, Helen E, Hardman, Clare S, Sivasubramaniam, Meera, Szeto, Aydan, Cohen, E Suzanne, Scott, Ian C, Sleeman, Matthew A, Chidomere, Chiamaka I, Cruz Migoni, Sara, Caamano, Jorge, Jorgensen, Helle F, Carobbio, Stefania, Vidal-Puig, Antonio, McKenzie, Andrew N J
Format:	Article
Language:	eng
Subjects:	Adipose Tissue, White - cytology Animals Cell Proliferation Eosinophils - metabolism Immunity, Innate Interleukin-33 Interleukin-5 - biosynthesis Lymphocytes - cytology Lymphocytes - immunology Mice, Inbred BALB C Mice, Inbred C57BL Stromal Cells - cytology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.
ISSN:	0022-1007 1540-9538