Depressive symptoms and immune transcriptional profiles in late adolescents

•Depressed mood was linked to upregulated expression inflammation-related genes.•Depressed mood was linked to downregulated expression of antiviral-related genes.•This pattern was mediated by greater NF-κB activity and reduced GR and IRF activity.•Cellular sources of this pattern included monocytes,...

Full description

Saved in:
Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2019-08, Vol.80, p.163-169
Main Authors: Chiang, Jessica J., Cole, Steve W., Bower, Julienne E., Irwin, Michael R., Taylor, Shelley E., Arevalo, Jesusa, Fuligni, Andrew J.
Format: Article
Language:English
Subjects:
Adolescent
Depression - genetics
Depression - immunology
Depression - metabolism
Depressive Disorder - immunology
Depressive Disorder - metabolism
Female
Gene Expression Profiling - methods
Gene Expression Regulation - genetics
Genomics - methods
Humans
Inflammation - blood
Male
NF-kappa B - genetics
Receptors, Glucocorticoid - genetics
Transcriptome - genetics
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Depressed mood was linked to upregulated expression inflammation-related genes.•Depressed mood was linked to downregulated expression of antiviral-related genes.•This pattern was mediated by greater NF-κB activity and reduced GR and IRF activity.•Cellular sources of this pattern included monocytes, B cells, and dendritic cells. Rates of depression increase and peak during late adolescence and alterations in immune processes are thought to be both a risk factor and outcome of depression. However, few studies have examined depression-immune dynamics among adolescents. Using a functional genomics approach, the current study examined whether depressive symptoms were associated with activation of a gene expression profile, characterized by upregulated expression of pro-inflammatory-related genes and downregulated expression of antiviral-related genes in a sample of older adolescents (Mage = 18.37, SD = 0.51). Participants (n = 87) reported on their depressive symptoms during the past week using the CES-D, and provided blood samples for genome-wide transcriptional profiling of mRNA. Adolescents with clinically-significant levels of depressive symptoms (CES-D ≥ 16) exhibited upregulated expression of inflammation-related genes and downregulated expression of antiviral-related genes compared to their peers with lower levels of depressive symptoms (CES-D 
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2019.03.004