Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemophotothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2019-08, Vol.116 (34), p.16729-16735
Main Authors: Sun, Yue, Ding, Feng, Chen, Zhao, Zhang, Ruiping, Li, Chonglu, Xu, Yuling, Zhang, Yi, Ni, Ruidong, Li, Xiaopeng, Yang, Guangfu, Sun, Yao, Stang, Peter J.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Biocompatibility
Biomedical materials
Cell Line, Tumor
Chemical compounds
Fluorescence
Fluorescent dyes
Fluorescent indicators
Hyperthermia, Induced
Imaging
Infrared Rays
Melanin
Melanins - chemistry
Mice, Inbred C57BL
Multimodal Imaging
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Organometallic compounds
Pharmacology
Photoacoustic Techniques
Phototherapy
Physical Sciences
Platinum - pharmacology
Proton Magnetic Resonance Spectroscopy
Side effects
Therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemophotothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1908761116