Parallel processing of environmental recognition and locomotion in the mouse striatum

Information processing in behaving animals has been the target of many studies in the striatum; however, its dynamics and complexity remain to a large extent unknown. Here, we chronically recorded neuronal populations in dorsal striatum as mice were exposed to a novel environment, a paradigm which e...

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Bibliographic Details
Published in:The Journal of neuroscience 2013-01, Vol.33 (2), p.473-484
Main Authors: Yamin, Hagar G, Stern, Edward A, Cohen, Dana
Format: Article
Language:English
Subjects:
Algorithms
Animals
Behavior, Animal - physiology
Data Interpretation, Statistical
Electrodes, Implanted
Electrophysiological Phenomena
Environment
Female
Interneurons - physiology
Least-Squares Analysis
Locomotion - physiology
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Neostriatum - cytology
Neostriatum - physiology
Neurons - classification
Neurons - physiology
Neurons - ultrastructure
Poisson Distribution
Recognition (Psychology) - physiology
Support Vector Machine
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Summary:Information processing in behaving animals has been the target of many studies in the striatum; however, its dynamics and complexity remain to a large extent unknown. Here, we chronically recorded neuronal populations in dorsal striatum as mice were exposed to a novel environment, a paradigm which enables the dissociation of locomotion and environmental recognition. The findings indicate that non-overlapping populations of striatal projection neurons-the medium spiny neurons-reliably encode locomotion and environmental identity, whereas two subpopulations of short-spike interneurons encode distinct information: the fast spiking interneurons preferentially encode locomotion whereas the second type of interneurons preferentially encodes environmental identity. The three neuronal subgroups used cell-type specific coding schemes. This study provides evidence for the existence of parallel processing circuits within the sensorimotor region of the striatum.
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/jneurosci.4474-12.2013