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Selective Depletion and Enrichment of Constituents in “Curcumin” and Other Curcuma longa Preparations
Much uncertainty exists in science and herbal products referencing turmeric (T), turmeric extract (TE), curcuminoid-enriched turmeric extract (CTE), further processed curcuminoid-enriched materials (CEM), or curcumin as a single-chemical entity. To facilitate the rational chemical and biological ass...
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Published in: | Journal of natural products (Washington, D.C.) D.C.), 2019-03, Vol.82 (3), p.621-630 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Much uncertainty exists in science and herbal products referencing turmeric (T), turmeric extract (TE), curcuminoid-enriched turmeric extract (CTE), further processed curcuminoid-enriched materials (CEM), or curcumin as a single-chemical entity. To facilitate the rational chemical and biological assessment of turmeric-derived NPs, we introduced the DESIGNER approach of Depleting and Enriching Select Ingredients to Generate Normalized Extract Resources to Curcuma longa preparations. Countercurrent separation of a commercial CTE yielded four key materialslipophilic metabolites; purified curcumin (“purcumin”); a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin (“purcuminoids”); and hydrophilic metabolitesand enabled production of a curcuminoid-free TE (“nocumin”). Their characterization utilized TLC, 1H (q)NMR spectroscopy, and HPLC. |
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ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/acs.jnatprod.9b00020 |