Selective Depletion and Enrichment of Constituents in “Curcumin” and Other Curcuma longa Preparations

Much uncertainty exists in science and herbal products referencing turmeric (T), turmeric extract (TE), curcuminoid-enriched turmeric extract (CTE), further processed curcuminoid-enriched materials (CEM), or curcumin as a single-chemical entity. To facilitate the rational chemical and biological ass...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2019-03, Vol.82 (3), p.621-630
Main Authors: Friesen, J. Brent, Liu, Yang, Chen, Shao-Nong, McAlpine, James B, Pauli, Guido F
Format: Article
Language:English
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Summary:Much uncertainty exists in science and herbal products referencing turmeric (T), turmeric extract (TE), curcuminoid-enriched turmeric extract (CTE), further processed curcuminoid-enriched materials (CEM), or curcumin as a single-chemical entity. To facilitate the rational chemical and biological assessment of turmeric-derived NPs, we introduced the DESIGNER approach of Depleting and Enriching Select Ingredients to Generate Normalized Extract Resources to Curcuma longa preparations. Countercurrent separation of a commercial CTE yielded four key materialslipophilic metabolites; purified curcumin (“purcumin”); a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin (“purcuminoids”); and hydrophilic metabolitesand enabled production of a curcuminoid-free TE (“nocumin”). Their characterization utilized TLC, 1H (q)­NMR spectroscopy, and HPLC.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b00020