Plasma Membrane Ca2+ ATPase 2 Contributes to Short-Term Synapse Plasticity at the Parallel Fiber to Purkinje Neuron Synapse

Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2-/- knock-out mice all poi...

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Bibliographic Details
Published in:The Journal of neuroscience 2007-04, Vol.27 (14), p.3753-3758
Main Authors: Empson, Ruth M, Garside, Molly L, Knopfel, Thomas
Format: Article
Language:English
Subjects:
Animals
Brief Communications
Cerebellum - enzymology
Female
Isoenzymes - deficiency
Isoenzymes - genetics
Isoenzymes - physiology
Male
Mice
Mice, Knockout
Muscle Fibers, Fast-Twitch - enzymology
Neuronal Plasticity - physiology
Plasma Membrane Calcium-Transporting ATPases - deficiency
Plasma Membrane Calcium-Transporting ATPases - genetics
Plasma Membrane Calcium-Transporting ATPases - physiology
Purkinje Cells - enzymology
Reaction Time
Synapses - enzymology
Synapses - genetics
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Summary:Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2-/- knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.0069-07.2007