Effect of mosapride on ruminal motility in cattle

This study aimed to assess the effects of mosapride at various dosages on ruminal motility in cattle and the absorption kinetics of mosapride in cattle. Mosapride was rapidly absorbed after oral administration in cattle. Oral administration at dosages of 1, 3, and 10 mg/kg resulted in a dose-depende...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2019, Vol.81(7), pp.1017-1020
Main Authors: ARAI, Shozo, HARITANI, Makoto, SAWADA, Hiroshi, KIMURA, Kumiko
Format: Article
Language:English
Subjects:
Bovidae
Cattle
Dosage
Internal Medicine
Kinetics
mosapride
Motility
Oral administration
ruminal motility
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Summary:This study aimed to assess the effects of mosapride at various dosages on ruminal motility in cattle and the absorption kinetics of mosapride in cattle. Mosapride was rapidly absorbed after oral administration in cattle. Oral administration at dosages of 1, 3, and 10 mg/kg resulted in a dose-dependent increase in the detection time. At the 1 mg/kg dose, the motility index of rumen in cattle significantly increased at 60, 70, and 80 min (134 ± 20, 168 ± 37, 173 ± 45%, respectively), compared with that of the control. The administration of mosapride in cattle did not cause any subsequent adverse clinical signs or blood test abnormalities. It was suggested that mosapride enhanced ruminal motility without adverse effects in cattle.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.19-0196