Evaluation of ischemia-modified albumin in anemia associated to chronic kidney disease

Chronic kidney disease (CKD) is highly prevalent, with increasing numbers of patients affected by the disease world‐wide, and anemia is a common finding in patients with CKD. Anemia impacts negatively on cardiovascular disease, exercise capacity, and quality of life, resulting in significant mortali...

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Published in:Journal of clinical laboratory analysis 2008, Vol.22 (1), p.1-5
Main Authors: Cichota, Luiz Carlos, Moresco, Rafael Noal, Duarte, Marta Maria Medeiros Frescura, Silva, José Edson Paz da
Format: Article
Language:English
Subjects:
Adult
Aged
anemia
Anemia - blood
Anemia - complications
Case-Control Studies
Creatinine - blood
Female
hemoglobin
Hemoglobins - analysis
Hemoglobins - metabolism
Humans
ischemia
Ischemia - blood
Ischemia - complications
ischemia-modified albumin
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - complications
lactate
Lactic Acid - blood
Male
Middle Aged
Original
Serum Albumin - analysis
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Summary:Chronic kidney disease (CKD) is highly prevalent, with increasing numbers of patients affected by the disease world‐wide, and anemia is a common finding in patients with CKD. Anemia impacts negatively on cardiovascular disease, exercise capacity, and quality of life, resulting in significant mortality and morbidity. The aim of this study was to evaluate the levels of ischemia‐modified albumin and lactate in patients with established anemia associated with CKD and its correlations with hemoglobin levels. Hematocrit, hemoglobin, iron, ferritin, albumin, creatinine, lactate, and ischemia‐modified albumin (IMA) were measured in 17 patients with established anemia associated to CKD and 19 controls by standard methods. The results of hematocrit, hemoglobin, iron, and albumin were lower in the anemia group than in the control group. Ferritin, creatinine, and lactate levels were higher in anemia of the CKD group than the control group. IMA increase in the anemia group (0.8115±0.1304 absorbance units [ABSU]) compared to control (0.4951±0.0393 ABSU). Significant correlations between IMA and lactate, IMA and hemoglobin, IMA and creatinine, and hemoglobin and lactate were observed. IMA and lactate increase during anemia and this elevation could be associated to hypoxia due to low hemoglobin levels. However, our data suggest that lactate is more sensitive to anemia compared to IMA. J. Clin. Lab. Anal. 22:1–5, 2008. © 2008 Wiley‐Liss, Inc.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.20226