Factors Influencing Aspirin Hyporesponsiveness in Elderly Chinese Patients

BACKGROUND Aspirin hyporesponsiveness increases the risk of ischemic events. Therefore, it is important to investigate the factors influencing aspirin hyporesponsiveness. MATERIAL AND METHODS Patients aged 60 years or older who did not take aspirin before enrollment were included, with aspirin 100 m...

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Bibliographic Details
Published in:Medical science monitor 2019-07, Vol.25, p.5191-5200
Main Authors: Ou, Wei Mei, Fu, Zhi Fang, Chen, Xia Huan, Feng, Xue Ru, Li, Hai Xia, Lu, Yao, Liu, Mei, Huang, Bo, Liu, Wen Wen, Liu, Mei Lin
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Aspirin - administration & dosage
Biomarkers, Pharmacological - metabolism
China
Clinical Research
Female
Humans
Male
Middle Aged
Odds Ratio
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - pharmacology
Platelet Function Tests
Uric Acid - analysis
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Summary:BACKGROUND Aspirin hyporesponsiveness increases the risk of ischemic events. Therefore, it is important to investigate the factors influencing aspirin hyporesponsiveness. MATERIAL AND METHODS Patients aged 60 years or older who did not take aspirin before enrollment were included, with aspirin 100 mg/day administered after enrollment. The arachidonic acid-induced platelet aggregation rate (Ara) was measured by light transmission assay to evaluate aspirin responsiveness. Patients with Ara in the upper quartile after taking aspirin were assigned to the aspirin hyporesponsive group (Ara-Q4). RESULTS A total of 292 elderly patients were included. The median value of Ara after taking aspirin was 5.87% (interquartile range 3.86-10.04%). Compared with the aspirin non-hyporesponsive group (Ara-Q1-3, Ara ≤10.04%, n=220), the level of uric acid (UA) (341.30 µmol/L vs. 299.10 µmol/L, p=0.027) and the ratios of ß-blockers (9.72% vs. 2.27%, p=0.015) and diuretics (6.94% vs. 1.36%, p=0.036) were higher in the aspirin hyporesponsive group (Ara-Q4, Ara >10.04%, n=72). After multivariate adjustment, the results demonstrated baseline Ara (odds ratio [OR]: 1.030, 95% confidence interval [CI]: 1.004-1.056, p=0.021), UA level (OR: 1.003, 95% CI: 1.000-1.006, p=0.038), and ß-blockers use (OR: 5.487, 95% CI: 1.515-19.870, p=0.010) were independently and positively associated with aspirin hyporesponsiveness. CONCLUSIONS This study found that baseline Ara, UA level, and ß-blockers use were independently and positively associated with aspirin hyporesponsiveness in elderly Chinese patients, which needs to be validated in large-scale studies.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.917654