The hallmarks of CMV-specific CD8 T-cell differentiation

Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced d...

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Bibliographic Details
Published in:Medical microbiology and immunology 2019-08, Vol.208 (3-4), p.365-373
Main Authors: van den Berg, Sara P. H., Pardieck, Iris N., Lanfermeijer, Josien, Sauce, Delphine, Klenerman, Paul, van Baarle, Debbie, Arens, Ramon
Format: Article
Language:English
Subjects:
Aging
Aging (natural)
Antigen T (large)
Biomedical and Life Sciences
Biomedicine
CD45 antigen
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation
Cytokines
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus Infections - immunology
Cytotoxicity
Gene Expression
Homing
Immunologic Factors - biosynthesis
Immunological memory
Immunology
Isoforms
Life Sciences
Lymphocytes
Lymphocytes T
Medical Microbiology
Memory cells
Phenotypes
Review
T-Lymphocyte Subsets - immunology
The Special Issue on Immunological Imprinting during Chronic Viral Infection
Transcription factors
Virology
Viruses
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Summary:Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this “special” differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.
ISSN:0300-8584
1432-1831
DOI:10.1007/s00430-019-00608-7