Randomized within‐subject trial to evaluate smokers’ initial perceptions, subjective effects and nicotine delivery across six vaporized nicotine products

Background and Aims Vaporized nicotine products (VNPs) can vary in important characteristics including size, shape, flavor and nicotine yield. We examined whether complex interactions among these characteristics could affect smokers’ VNP perceptions and usage patterns. Design A within‐subject random...

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Bibliographic Details
Published in:Addiction (Abingdon, England) England), 2019-07, Vol.114 (7), p.1236-1248
Main Authors: Voos, Natalie, Kaiser, Lisa, Mahoney, Martin C., Bradizza, Clara M., Kozlowski, Lynn T., Benowitz, Neal L., O'Connor, Richard J., Goniewicz, Maciej L.
Format: Article
Language:English
Subjects:
Adult
Attitude
Blood tests
Cancer
Cigarette Smoking
Cigarettes
Cross-Over Studies
Ego
electronic cigarettes
electronic delivery systems
Electronic Nicotine Delivery Systems - statistics & numerical data
Embarrassment
e‐cigarettes
Female
Flavor
Health risks
Humans
Male
Middle Aged
Nicotine
Nicotine - administration & dosage
Nicotine - pharmacokinetics
Nicotinic Agonists - administration & dosage
Nicotinic Agonists - pharmacokinetics
Perceptions
Personal Satisfaction
Pharynx
Pipes
Questionnaires
Random Allocation
Randomization
Ratings & rankings
Risk perception
Smokers
Smoking
Taste
Tobacco
Tobacco Use Disorder
Vaping
vaporizers
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Summary:Background and Aims Vaporized nicotine products (VNPs) can vary in important characteristics including size, shape, flavor and nicotine yield. We examined whether complex interactions among these characteristics could affect smokers’ VNP perceptions and usage patterns. Design A within‐subject randomized cross‐over trial. Setting Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Participants Eighteen daily cigarette smokers. Measurements Participants attended eight weekly visits during which they sampled six different VNPs (disposable, rechargeable, eGO, mod, e‐Cigar and e‐Pipe) with tobacco‐flavored e‐liquid. Prior to device use, participants completed product‐ranking questionnaires. Participants completed controlled puffing sessions during each of the six trials, after which satisfaction questionnaires were completed and blood samples were taken. Findings Initial perceptions showed that the smallest device (disposable) was ranked as safer compared with a larger device (e‐Pipe) (P 
ISSN:0965-2140
1360-0443
DOI:10.1111/add.14602