Effect of antioxidants on BPA-induced stress on sperm function in a mouse model

In the past few years, bisphenol A, (BPA) an endocrine-disrupting chemical, has received increasing attention because of its detrimental health effects. There is ample evidence to support that BPA interferes with the reproductive health of humans and animals. In spermatozoa, BPA-induced adverse effe...

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Bibliographic Details
Published in:Scientific reports 2019-07, Vol.9 (1), p.10584-10, Article 10584
Main Authors: Rahman, Md Saidur, Kang, Kyu-Ho, Arifuzzaman, Sarder, Pang, Won-Ki, Ryu, Do-Yeal, Song, Won-Hee, Park, Yoo-Jin, Pang, Myung-Geol
Format: Article
Language:English
Subjects:
Acrosome reaction
Animals
Antioxidants
Antioxidants - pharmacology
Ascorbic acid
Ascorbic Acid - pharmacology
Benzhydryl Compounds - adverse effects
Benzhydryl Compounds - pharmacology
Bisphenol A
Congenital Abnormalities
Endocrine disruptors
Fertility
Fertilization
Glutathione
Glutathione - pharmacology
Kinases
Male
Mice
Oxidative stress
Phenols - adverse effects
Phenols - pharmacology
Phosphorylation
Protein kinase A
Reactive oxygen species
Reproductive health
Scapula - abnormalities
Scapula - drug effects
Shoulder Joint - abnormalities
Shoulder Joint - drug effects
Sperm
Sperm Motility - drug effects
Stress, Physiological - drug effects
Supplements
Tyrosine
Vitamin E
Vitamin E - pharmacology
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Summary:In the past few years, bisphenol A, (BPA) an endocrine-disrupting chemical, has received increasing attention because of its detrimental health effects. There is ample evidence to support that BPA interferes with the reproductive health of humans and animals. In spermatozoa, BPA-induced adverse effects are mostly caused by increased oxidative stress. Using an in vitro experimental model, we examined whether antioxidants (glutathione, vitamin C, and vitamin E) have defensive effects against BPA-induced stress in spermatozoa. The results showed that antioxidants inhibit the overproduction of reactive oxygen species (basically cellular peroxides) and increase intracellular ATP levels, thereby preventing motility loss and abnormal acrosome reaction in BPA-exposed spermatozoa. In particular, glutathione and vitamin E reduced the protein kinase A-dependent tyrosine phosphorylation in spermatozoa and, thus, prevented the precocious acrosome reaction from occurring. Furthermore, we found that the compromised fertilisation and early embryo development mediated by BPA-exposed spermatozoa can be improved following their supplementation with glutathione and vitamin E. Based on these findings, we suggest that antioxidants reduce oxidative stress in BPA-exposed spermatozoa, thus preventing detrimental effects on their function and fertility.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-47158-9