Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden

Background Blood pressure visit-to-visit variability is a novel risk factor for deleterious long-term cardiac and renal outcomes in the general population. We hypothesized that patients with systemic lupus erythematosus (SLE) have greater blood pressure visit-to-visit variability than control subjec...

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Bibliographic Details
Published in:Lupus 2019-07, Vol.28 (8), p.954-960
Main Authors: Reese, T, Dickson, A L, Shuey, M M, Gandelman, J S, Barnado, A, Barker, K A, Neal, J E, Khan, O A, Dupont, W D, Stein, C M, Chung, C P
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Antihypertensives
Blood pressure
Blood Pressure - drug effects
Case-Control Studies
Comorbidity
Corticosteroids
Creatinine
Cyclophosphamide
Cyclophosphamide - therapeutic use
Databases, Factual
Electronic medical records
Female
Humans
Hydroxychloroquine
Hydroxychloroquine - therapeutic use
Hypertension - drug therapy
Hypertension - epidemiology
Inflammation - complications
Logistic Models
Lupus
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - epidemiology
Male
Middle Aged
Multivariate Analysis
Mycophenolate mofetil
Mycophenolic acid
Mycophenolic Acid - therapeutic use
Patients
Risk Factors
Severity of Illness Index
Systemic lupus erythematosus
Variation
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Summary:Background Blood pressure visit-to-visit variability is a novel risk factor for deleterious long-term cardiac and renal outcomes in the general population. We hypothesized that patients with systemic lupus erythematosus (SLE) have greater blood pressure visit-to-visit variability than control subjects and that blood pressure visit-to-visit variability is associated with a higher comorbidity burden. Methods We studied 899 patients with SLE and 4172 matched controls using de-identified electronic health records from an academic medical center. We compared blood pressure visit-to-visit variability measures in patients with SLE and control subjects and examined the association between blood pressure visit-to-visit variability and patients’ characteristics. Results Patients with SLE had higher systolic blood pressure visit-to-visit variability 9.7% (7.8–11.8%) than the control group 9.2% (7.4–11.2%), P 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203319856988