CaM Kinase II and Visual Input Modulate Memory Formation in the Neuronal Circuit Controlling Courtship Conditioning

In Drosophila, calcium/calmodulin-dependent protein kinase II (CaM kinase) has been shown to be important in the expression of both learning and memory for the associative behavior courtship conditioning. In this study we examine the role of visual input in producing this behavior and the effects of...

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Bibliographic Details
Published in:The Journal of neuroscience 1997-12, Vol.17 (23), p.9384-9391
Main Authors: Joiner, Mei-ling A, Griffith, Leslie C
Format: Article
Language:English
Subjects:
Animals
Association Learning - physiology
Avoidance Learning - physiology
Brain Chemistry
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases - physiology
Conditioning, Classical - physiology
Courtship
Drosophila melanogaster - enzymology
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Enzyme Inhibitors
Eye Color - genetics
Female
Gene Expression Regulation
Male
Memory - physiology
Mental Recall - physiology
Nerve Tissue Proteins - physiology
Neuronal Plasticity - physiology
Neurons - physiology
Peptides
Pheromones - physiology
Photic Stimulation
Proteins - genetics
Proteins - physiology
Recombinant Fusion Proteins - physiology
Sexual Behavior, Animal - radiation effects
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Summary:In Drosophila, calcium/calmodulin-dependent protein kinase II (CaM kinase) has been shown to be important in the expression of both learning and memory for the associative behavior courtship conditioning. In this study we examine the role of visual input in producing this behavior and the effects of modifying visual input on CaM kinase-dependent memory formation. Inhibition of CaM kinase blocked apparent learning regardless of visual input. Visual input selectively affected the memory phase of courtship conditioning: normal visual input masked the memory effects of inhibition of CaM kinase resulting in generation of memory without apparent learning, whereas disruption of visual input revealed the CaM kinase-dependence of memory. Visual input was found to be important only during the training period, which implies that vision and CaM kinase are interacting in the formation rather than the retrieval of memory. Our results suggest a model for courtship conditioning in which multiple sensory inputs are integrated at a CaM-kinase-dependent neuronal switch to modulate courtship behavior.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.17-23-09384.1997