Activity/exercise-induced changes in the liver transcriptome after chronic spinal cord injury

Multi-organ dysfunction is a major complication after spinal cord injury (SCI). In addition to local injury within the spinal cord, SCI causes major disruption to the peripheral organ innervation and regulation. The liver contains sympathetic, parasympathetic, and small sensory axons. The bi-directi...

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Bibliographic Details
Published in:Scientific data 2019-06, Vol.6 (1), p.88-9, Article 88
Main Authors: Chariker, Julia H, Ohri, Sujata Saraswat, Gomes, Cynthia, Brabazon, Fiona, Harman, Kathryn A, DeVeau, Kathryn M, Magnuson, David S K, Hetman, Michal, Petruska, Jeffrey C, Whittemore, Scott R, Rouchka, Eric C
Format: Article
Language:English
Subjects:
Animals
Axons
Chronic Disease
Data Descriptor
Dorsal root ganglia
Gene expression
Genomes
Innervation
Liver
Liver - metabolism
Motor Activity
Parasympathetic nervous system
Physical Conditioning, Animal
Rats
Ribonucleic acid
RNA
Sense organs
Sensory neurons
Spinal cord injuries
Spinal Cord Injuries - metabolism
Spinal Cord Injuries - physiopathology
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Summary:Multi-organ dysfunction is a major complication after spinal cord injury (SCI). In addition to local injury within the spinal cord, SCI causes major disruption to the peripheral organ innervation and regulation. The liver contains sympathetic, parasympathetic, and small sensory axons. The bi-directional signaling of sensory dorsal root ganglion (DRG) neurons that provide both efferent and afferent information is of key importance as it allows sensory neurons and peripheral organs to affect each other. SCI-induced liver inflammation precedes and may exacerbate intraspinal inflammation and pathology after SCI, which may be modulated by activity and exercise. In this study, we collected comprehensive gene expression data through RNA sequencing of liver tissue from rats with chronic SCI to determine the effects of activity and exercise on those expression patterns. The sequenced data are of high quality and show a high alignment rate to the Rn6 genome. Gene expression is demonstrated for genes associated with known liver pathologies. UCSC Genome Browser expression tracks are provided with the data to facilitate exploration of the samples.
ISSN:2052-4463
2052-4463
DOI:10.1038/s41597-019-0087-5