Metabolomic assessment of exposure to near-highway ultrafine particles

Exposure to traffic-related air pollutants has been associated with increased risk of adverse cardiopulmonary outcomes and mortality; however, the biochemical pathways linking exposure to disease are not known. To delineate biological response mechanisms associated with exposure to near-highway ultr...

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Bibliographic Details
Published in:Journal of exposure science & environmental epidemiology 2019-06, Vol.29 (4), p.469-483
Main Authors: Walker, Douglas I, Lane, Kevin J, Liu, Ken, Uppal, Karan, Patton, Allison P, Durant, John L, Jones, Dean P, Brugge, Doug, Pennell, Kurt D
Format: Article
Language:English
Subjects:
Air Pollutants - analysis
Air pollution
Antioxidants
Arginine
Aspartic acid
Automotive emissions
Bioenergetics
Biomarkers
Biomarkers - analysis
Correlation analysis
Cross-Sectional Studies
Cystine
Environmental Exposure
Exposure
Female
Glutamine
Health aspects
Heart diseases
Highways
Humans
Lipid peroxidation
Lipids
Lung diseases
Male
Medical research
Medicine, Experimental
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Methionine
Middle Aged
Mitochondria
Nitric oxide
Particles
Particulate Matter - analysis
Peroxidation
Physiological aspects
Pollutants
Reactive oxygen species
Risk factors
Ultrafines
Variation
Vehicle emissions
Vehicle Emissions - analysis
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Summary:Exposure to traffic-related air pollutants has been associated with increased risk of adverse cardiopulmonary outcomes and mortality; however, the biochemical pathways linking exposure to disease are not known. To delineate biological response mechanisms associated with exposure to near-highway ultrafine particles (UFP), we used untargeted high-resolution metabolomics to profile plasma from 59 participants enrolled in the Community Assessment of Freeway Exposure and Health (CAFEH) study. Metabolic variations associated with UFP exposure were assessed using a cross-sectional study design based upon low (mean 16,000 particles/cm ) and high (mean 24,000 particles/cm ) annual average UFP exposures. In comparing quantified metabolites, we identified five metabolites that were differentially expressed between low and high exposures, including arginine, aspartic acid, glutamine, cystine and methionine sulfoxide. Analysis of the metabolome identified 316 m/z features associated with UFP, which were consistent with increased lipid peroxidation, endogenous inhibitors of nitric oxide and vehicle exhaust exposure biomarkers. Network correlation analysis and metabolic pathway enrichment identified 38 pathways and included variations related to inflammation, endothelial function and mitochondrial bioenergetics. Taken together, these results suggest UFP exposure is associated with a complex series of metabolic variations related to antioxidant pathways, in vivo generation of reactive oxygen species and processes critical to endothelial function.
ISSN:1559-0631
1559-064X
1559-064X
DOI:10.1038/s41370-018-0102-5