A community‐engaged approach to investigate cardiovascular‐associated inflammation among American Indian women: A research protocol

American Indian women are more likely to die from cardiovascular disease (CVD) than White or African American women. Inflammatory processes may underlie CVD disparities by gender and race and may be critical to understanding population‐specific drivers and potential buffers. Exposure to environmenta...

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Bibliographic Details
Published in:Research in nursing & health 2019-06, Vol.42 (3), p.165-175
Main Authors: Brooks, Jada L., Berry, Diane C., Currin, Emily G., Ledford, Alasia, Knafl, George J., Fredrickson, Barbara L., Beeber, Linda S., Peden, David B., Corbie‐Smith, Giselle M.
Format: Article
Language:English
Subjects:
Adult
adulthood
African Americans
Air Pollution - adverse effects
American Indians
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - prevention & control
Clinical Protocols - standards
community‐based participatory research
cultural research
design development
Emotions
environment
Environmental Exposure - adverse effects
Female
Gender
Gender inequality
Gene expression
Health disparities
Health status
Humans
Indians, North American
Inflammation
Inflammation - ethnology
Inflammation - prevention & control
Infrastructure
Medical research
Mental depression
Mental Health - ethnology
Middle Aged
Morbidity
Mortality
Native North Americans
Participatory research
physiological states
Pollutants
Positive emotions
Post traumatic stress disorder
Psychological aspects
Race
Recruitment
Socioeconomic Factors
Symptoms
Womens health
women’s health
Young Adult
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Summary:American Indian women are more likely to die from cardiovascular disease (CVD) than White or African American women. Inflammatory processes may underlie CVD disparities by gender and race and may be critical to understanding population‐specific drivers and potential buffers. Exposure to environmental air pollutants, especially particulate matter (PM), is known to be an important catalyst in CVD‐associated inflammation. Positive psychological states, associated with low levels of inflammatory gene expression, could serve to moderate the inflammatory response to environmental air pollutants and ultimately lead to better cardiovascular health outcomes. The aim of the ongoing community‐engaged and NIH‐funded study described in this study protocol is to address the racial and gender gaps in CVD mortality by investigating the contextually relevant and culturally important determinants of health among American Indian women. In this paper we describe the procedures used to examine the relationship between environmental air pollutant exposures (PM10‐2.5 and PM 2.5), psychological factors (e.g., depressive symptoms, posttraumatic stress symptoms, eudemonic well‐being, and positive emotions), and cardiovascular‐associated inflammation (hs‐CRP, IL‐6, Amyloid A, CBCs with differentials) in a sample of 150 women 18–50 years of age from the Lumbee Tribe in southeastern North Carolina. We describe lessons learned and strategies used in developing a community‐engaged approach to enhance recruitment of American Indian women in biomedical research. The empirical data and community infrastructure resulting from this study will be foundational in designing and testing future interventions to reduce CVD‐associated morbidity and mortality in American Indian women.
ISSN:0160-6891
1098-240X
DOI:10.1002/nur.21944