Reprogramming Cells to Make Insulin

Type 1 diabetes is a disease characterized by the destruction of insulin-secreting -cells in the pancreas. Individuals are treated for this disease with lifelong insulin replacement. However, one attractive treatment possibility is to reprogram an individual's endogenous cells to acquire the ab...

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Bibliographic Details
Published in:Journal of the Endocrine Society 2019-06, Vol.3 (6), p.1214-1226
Main Authors: McKimpson, Wendy M, Accili, Domenico
Format: Article
Language:English
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Summary:Type 1 diabetes is a disease characterized by the destruction of insulin-secreting -cells in the pancreas. Individuals are treated for this disease with lifelong insulin replacement. However, one attractive treatment possibility is to reprogram an individual's endogenous cells to acquire the ability to secrete insulin, essentially replacing destroyed -cells. Herein, we review the literature on the topic of reprogramming endodermal cells to produce insulin.
ISSN:2472-1972
2472-1972
DOI:10.1210/js.2019-00040