Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals

The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta‐analysis at the individual patients level to capture the possible effect of ethnicity, gene—gene interaction, or other drugs on the association and to verify if inclusion...

Full description

Bibliographic Details

Published in:	Clinical pharmacology and therapeutics 2019-06, Vol.105 (6), p.1477-1491
Main Authors:	Danese, Elisa, Raimondi, Sara, Montagnana, Martina, Tagetti, Angela, Langaee, Taimour, Borgiani, Paola, Ciccacci, Cinzia, Carcas, Antonio J., Borobia, Alberto M., Tong, Hoi Y., Dávila‐Fajardo, Cristina, Rodrigues Botton, Mariana, Bourgeois, Stephane, Deloukas, Panos, Caldwell, Michael D., Burmester, Jim K., Berg, Richard L., Cavallari, Larisa H., Drozda, Katarzyna, Huang, Min, Zhao, Li‐Zi, Cen, Han‐Jing, Gonzalez‐Conejero, Rocio, Roldan, Vanessa, Nakamura, Yusuke, Mushiroda, Taisei, Gong, Inna Y., Kim, Richard B., Hirai, Keita, Itoh, Kunihiko, Isaza, Carlos, Beltrán, Leonardo, Jiménez‐Varo, Enrique, Cañadas‐Garre, Marisa, Giontella, Alice, Kringen, Marianne K., Haug, Kari Bente Foss, Gwak, Hye Sun, Lee, Kyung Eun, Minuz, Pietro, Lee, Ming Ta Michael, Lubitz, Steven A., Scott, Stuart, Mazzaccara, Cristina, Sacchetti, Lucia, Genç, Ece, Özer, Mahmut, Pathare, Anil, Krishnamoorthy, Rajagopal, Paldi, Andras, Siguret, Virginie, Loriot, Marie‐Anne, Kutala, Vijay Kumar, Suarez‐Kurtz, Guilherme, Perini, Jamila, Denny, Josh C., Ramirez, Andrea H., Mittal, Balraj, Rathore, Saurabh Singh, Sagreiya, Hersh, Altman, Russ, Shahin, Mohamed Hossam A., Khalifa, Sherief I., Limdi, Nita A., Rivers, Charles, Shendre, Aditi, Dillon, Chrisly, Suriapranata, Ivet M., Zhou, Hong‐Hao, Tan, Sheng‐Lan, Tatarunas, Vacis, Lesauskaite, Vaiva, Zhang, Yumao, Maitland‐van der Zee, Anke H., Verhoef, Talitha I., Boer, Anthonius, Taljaard, Monica, Zambon, Carlo Federico, Pengo, Vittorio, Zhang, Jieying Eunice, Pirmohamed, Munir, Johnson, Julie A., Fava, Cristiano
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Cohort Studies Coumarins - administration & dosage Coumarins - adverse effects Cytochrome P-450 CYP2C9 - genetics Cytochrome P450 Family 4 - genetics Dose-Response Relationship, Drug Female Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics Vitamin K Epoxide Reductases - genetics
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!