Alteration of erythrocyte membrane polyunsaturated fatty acids in preterm newborns with retinopathy of prematurity

Extremely preterm infants are at high risk for retinopathy of prematurity (ROP), a potentially blinding disease characterized by abnormalities in retinal vascularization. Whereas animal studies revealed that n-3 polyunsaturated fatty acids (PUFAs) may be of benefit in preventing ROP, human studies c...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.7930-7930, Article 7930
Main Authors: Pallot, Charlotte, Mazzocco, Julie, Meillon, Cyril, Semama, Denis S, Chantegret, Corinne, Ternoy, Ninon, Martin, Delphine, Donier, Aurélie, Gregoire, Stéphane, Creuzot-Garcher, Catherine P, Bron, Alain M, Bretillon, Lionel, Acar, Niyazi
Format: Article
Language:English
Subjects:
Arachidonic acid
Baby foods
Bioavailability
Docosahexaenoic acid
Erythrocyte Membrane - pathology
Erythrocytes
Fatty acids
Fatty Acids, Omega-3 - analysis
Fatty Acids, Omega-6 - analysis
Fatty Acids, Unsaturated - analysis
Female
Food and Nutrition
Gestational Age
Human health and pathology
Humans
Infant, Newborn
Infant, Premature
Infants
Life Sciences
Neonates
Newborn babies
Placenta
Placental transfer
Polyunsaturated fatty acids
Prospective Studies
Retina
Retinopathy
Retinopathy of Prematurity - diagnosis
Retinopathy of Prematurity - pathology
Sensory Organs
Vascularization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extremely preterm infants are at high risk for retinopathy of prematurity (ROP), a potentially blinding disease characterized by abnormalities in retinal vascularization. Whereas animal studies revealed that n-3 polyunsaturated fatty acids (PUFAs) may be of benefit in preventing ROP, human studies conducted on preterm infants during the 1 weeks of life showed no association between blood n-3 PUFA bioavailability and ROP incidence and/or severity, probably because of the influence of nutrition on the lipid status of infants. In the OmegaROP prospective cohort study, we characterized the erythrocyte concentrations of PUFAs in preterm infants aged less than 29 weeks gestational age (GA) without any nutritional influence. We show that GA is positively associated with the erythrocyte n-6 to n-3 PUFA ratio, and particularly with the ratio of arachidonic acid (AA) to docosahexaenoic acid (DHA), in infants with ROP. A time-dependent accumulation of AA at the expense of DHA seems to occur in utero in erythrocytes of preterm infants who will develop ROP, thus reinforcing previous data on the beneficial properties of DHA on this disease. In addition, preliminary data on maternal erythrocyte membrane lipid concentrations suggest modifications in placental transfer of fatty acids. Documenting the erythrocyte AA to DHA ratio at birth in larger cohorts might be useful to set up new prognostic factors for ROP.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-44476-w