Time-restricted feeding improves adaptation to chronically alternating light-dark cycles

Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a strategy to minimize long term adverse metabolic...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.7874, Article 7874
Main Authors: Schilperoort, Maaike, van den Berg, Rosa, Dollé, Martijn E T, van Oostrom, Conny T M, Wagner, Karina, Tambyrajah, Lauren L, Wackers, Paul, Deboer, Tom, Hulsegge, Gerben, Proper, Karin I, van Steeg, Harry, Roenneberg, Till, Biermasz, Nienke R, Rensen, Patrick C N, Kooijman, Sander, van Kerkhof, Linda W M
Format: Article
Language:English
Subjects:
Animals
Body Temperature
Circadian rhythm
Circadian rhythms
Energy expenditure
Energy Metabolism
Fasting
Feeding
Female
Food availability
Food intake
Lipid Metabolism
Lipids - blood
Metabolic Diseases - blood
Metabolic Diseases - metabolism
Metabolic disorders
Metabolism
Mice
Photoperiod
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Summary:Disturbance of the circadian clock has been associated with increased risk of cardio-metabolic disorders. Previous studies showed that optimal timing of food intake can improve metabolic health. We hypothesized that time-restricted feeding could be a strategy to minimize long term adverse metabolic health effects of shift work and jetlag. In this study, we exposed female FVB mice to weekly alternating light-dark cycles (i.e. 12 h shifts) combined with ad libitum feeding, dark phase feeding or feeding at a fixed clock time, in the original dark phase. In contrast to our expectations, long-term disturbance of the circadian clock had only modest effects on metabolic parameters. Mice fed at a fixed time showed a delayed adaptation compared to ad libitum fed animals, in terms of the similarity in 24 h rhythm of core body temperature, in weeks when food was only available in the light phase. This was accompanied by increased plasma triglyceride levels and decreased energy expenditure, indicating a less favorable metabolic state. On the other hand, dark phase feeding accelerated adaptation of core body temperature and activity rhythms, however, did not improve the metabolic state of animals compared to ad libitum feeding. Taken together, restricting food intake to the active dark phase enhanced adaptation to shifts in the light-dark schedule, without significantly affecting metabolic parameters.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-44398-7