Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients

Inflammation in tumor microenvironments is implicated in the pathogenesis of tumor development. In particular, inflammasomes, which modulate innate immune functions, are linked to tumor growth and anticancer responses. However, the role of the NLRC4 inflammasome in gliomas remains unclear. Here, we...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.7895-7895, Article 7895
Main Authors: Lim, Jaejoon, Kim, Min Jun, Park, YoungJoon, Ahn, Ju Won, Hwang, So Jung, Moon, Jong-Seok, Cho, Kyung Gi, Kwack, KyuBum
Format: Article
Language:English
Subjects:
Adult
Aged
Astrocytes
Astrocytoma
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Brain - diagnostic imaging
Brain - immunology
Brain - pathology
Brain - surgery
Brain Neoplasms - diagnosis
Brain Neoplasms - genetics
Brain Neoplasms - immunology
Brain Neoplasms - mortality
Calcium-Binding Proteins - analysis
Calcium-Binding Proteins - metabolism
CARD Signaling Adaptor Proteins - analysis
CARD Signaling Adaptor Proteins - metabolism
Child
Datasets as Topic
Female
Gene Expression Regulation, Neoplastic - immunology
Genome-Wide Association Study
Genomes
Glioma
Glioma - diagnosis
Glioma - genetics
Glioma - immunology
Glioma - mortality
Humans
Immunohistochemistry
Inflammasomes
Inflammasomes - immunology
Inflammasomes - metabolism
Kaplan-Meier Estimate
Localization
Magnetic Resonance Imaging
Male
Medical prognosis
Microenvironments
Middle Aged
Prognosis
Sequence Analysis, DNA
Survival
Survival analysis
Therapeutic applications
Transcriptome - genetics
Tumor Microenvironment - genetics
Tumor Microenvironment - immunology
Up-Regulation
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Summary:Inflammation in tumor microenvironments is implicated in the pathogenesis of tumor development. In particular, inflammasomes, which modulate innate immune functions, are linked to tumor growth and anticancer responses. However, the role of the NLRC4 inflammasome in gliomas remains unclear. Here, we investigated whether the upregulation of the NLRC4 inflammasome is associated with the clinical prognosis of gliomas. We analyzed the protein expression and localization of NLRC4 in glioma tissues from 11 patients by immunohistochemistry. We examined the interaction between the expression of NLRC4 and clinical prognosis via a Kaplan-Meier survival analysis. The level of NLRC4 protein was increased in brain tissues, specifically, in astrocytes, from glioma patients. NLRC4 expression was associated with a poor prognosis in glioma patients, and the upregulation of NLRC4 in astrocytomas was associated with poor survival. Furthermore, hierarchical clustering of data from the Cancer Genome Atlas dataset showed that NLRC4 was highly expressed in gliomas relative to that in a normal healthy group. Our results suggest that the upregulation of the NLRC4 inflammasome contributes to a poor prognosis for gliomas and presents a potential therapeutic target and diagnostic marker.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-44261-9