Discovery of widespread type I and type V CRISPR-Cas inhibitors

Bacterial CRISPR-Cas systems protect their host from bacteriophages and other mobile genetic elements. Mobile elements, in turn, encode various anti-CRISPR (Acr) proteins to inhibit the immune function of CRISPR-Cas. To date, Acr proteins have been discovered for type I (subtypes I-D, I-E, and I-F)...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2018-10, Vol.362 (6411), p.240-242
Main Authors:	Marino, Nicole D, Zhang, Jenny Y, Borges, Adair L, Sousa, Alexander A, Leon, Lina M, Rauch, Benjamin J, Walton, Russell T, Berry, Joel D, Joung, J Keith, Kleinstiver, Benjamin P, Bondy-Denomy, Joseph
Format:	Article
Language:	eng
Subjects:	Bacteria Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Cell Line Computational Biology - methods CRISPR CRISPR-Cas Systems Endonucleases - antagonists & inhibitors Gene Editing Genes Genetic modification Genomes Humans Immune response Inhibitors Moraxella - genetics Nucleic acids Phages Proteins Pseudomonas - genetics
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