Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital discharge database, 2016

Massive use of antibiotics has led to increased bacterial resistance to these drugs, making infections more difficult to treat. Few studies have assessed the overall antimicrobial resistance (AMR) burden, and there is a paucity of comprehensive data to inform health policies. This study aims to asse...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2019-01, Vol.147, p.e144-e144, Article e144
Main Authors: Opatowski, M, Tuppin, P, Cosker, K, Touat, M, De Lagasnerie, G, Guillemot, D, Salomon, J, Brun-Buisson, C, Watier, L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bacteria
Bacteria - classification
Bacteria - drug effects
Bacteria - isolation & purification
Bacterial Infections
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Child
Child, Preschool
Drug Resistance, Bacterial
Female
France
France - epidemiology
Hospitalization
Hospitals
Human health and pathology
Humans
Incidence
Infant
Infant, Newborn
Infectious diseases
Life Sciences
Male
Middle Aged
Original Paper
Santé publique et épidémiologie
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Massive use of antibiotics has led to increased bacterial resistance to these drugs, making infections more difficult to treat. Few studies have assessed the overall antimicrobial resistance (AMR) burden, and there is a paucity of comprehensive data to inform health policies. This study aims to assess the overall annual incident number of hospitalised patients with AMR infection in France, using the National Hospital Discharge database. All incident hospitalisations with acute infections in 2016 were extracted. Infections which could be linked with an infecting microorganism were first analysed. Then, an extrapolation of bacterial species and resistance status was performed, according to age class, gender and infection site to estimate the total number of AMR cases. Resistant bacteria caused 139 105 (95% CI 127 920-150 289) infections, resulting in a 12.3% (95% CI 11.3-13.2) resistance rate. ESBL-producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus were the most common resistant bacteria (>50%), causing respectively 49 692 (95% CI 47 223-52 142) and 19 493 (95% CI 15 237-23 747) infections. Although assumptions are needed to provide national estimates, information from PMSI is comprehensive, covering all acute bacterial infections and a wide variety of microorganisms.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268819000402