Vaginal progesterone for prevention of preterm delivery in women with twin pregnancy: a randomized controlled trial

The aim of this study is to evaluate the efficacy of vaginal progesterone to prevent preterm delivery in twin pregnancies and its effect on perinatal outcome. A randomized, open label, controlled trial (NCT02350231) was carried out over 70 women, in three different hospitals in Egypt, between Februa...

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Published in:Facts, views & vision in ObGyn views & vision in ObGyn, 2018-06, Vol.10 (2), p.93-98
Main Authors: Shabaan, O M, Hassanin, I M, Makhlouf, A M, Salem, M N, Hussein, M, Mohamed, M, Abbas, A M
Format: Article
Language:English
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Summary:The aim of this study is to evaluate the efficacy of vaginal progesterone to prevent preterm delivery in twin pregnancies and its effect on perinatal outcome. A randomized, open label, controlled trial (NCT02350231) was carried out over 70 women, in three different hospitals in Egypt, between February 2015 and January 2017. All eligible pregnant women with twin pregnancies were randomly allocated in a 1:1 ratio into two groups. Group I (Progesterone group) was dispensed, 400 mg of progesterone through a vaginal pessary, each day at bedtime, from the 28th week of pregnancy until delivery. Group II (Control group) received no treatment other than the normal tonics taken during pregnancy. The two study groups were followed until delivery. The primary outcome was the rate of preterm delivery
ISSN:2032-0418