Vasculogenic properties of adventitial Sca-1 + CD45 + progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis

The cellular origins of vasa vasorum are ill-defined and may involve circulating or local progenitor cells. We previously discovered that murine aortic adventitia contains Sca-1 CD45 progenitors that produce macrophages. Here we investigated whether they are also vasculogenic. In aortas of C57BL/6 m...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.7286-7286, Article 7286
Main Authors: Toledo-Flores, Deborah, Williamson, Anna, Schwarz, Nisha, Fernando, Sanuja, Dimasi, Catherine, Witt, Tyra A, Nguyen, Thao M, Puranik, Amrutesh S, Chue, Colin D, Delacroix, Sinny, Spoon, Daniel B, Bonder, Claudine S, Bursill, Christina A, Di Bartolo, Belinda A, Nicholls, Stephen J, Simari, Robert D, Psaltis, Peter J
Format: Article
Language:English
Subjects:
Adventitia - cytology
Adventitia - pathology
Angiogenesis
Animals
Antigens, Ly - metabolism
Aorta
Aorta - cytology
Aorta - pathology
Apolipoprotein E
Arteriosclerosis
Atherogenesis
Atherogenic diet
Atherosclerosis
Atherosclerosis - etiology
Atherosclerosis - pathology
CD45 antigen
Cell Differentiation
Coronary vessels
Diet, Atherogenic
Disease Models, Animal
Endothelial cells
Endothelial Cells - physiology
Endothelium
Female
Flow cytometry
Humans
Ischemia
Leukocyte Common Antigens - metabolism
Macrophages
Macrophages - physiology
Male
Membrane Proteins - metabolism
Mice
Mice, Knockout, ApoE
Microscopy
Neovascularization, Pathologic - etiology
Neovascularization, Pathologic - pathology
Perfusion
Progenitor cells
Stem cells
Stem Cells - physiology
Vasa Vasorum - cytology
Vasa Vasorum - pathology
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Summary:The cellular origins of vasa vasorum are ill-defined and may involve circulating or local progenitor cells. We previously discovered that murine aortic adventitia contains Sca-1 CD45 progenitors that produce macrophages. Here we investigated whether they are also vasculogenic. In aortas of C57BL/6 mice, Sca-1 CD45 cells were localised to adventitia and lacked surface expression of endothelial markers (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-43765-8