Neutralization of Enterovirus D68 isolated from the 2014 US outbreak by commercial intravenous immune globulin products

Highlights • Developed an Enterovirus D68 (EV-D68)-specific microneutralization assay. • Detected high neutralizing antibody titers in intravenous immune globulin products. • Alignment of proposed antigenic sites may explain differences in titers. • Suggests possible effective treatment for primary...

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Bibliographic Details
Published in:Journal of clinical virology 2015-08, Vol.69, p.172-175
Main Authors: Zhang, Yiting, Moore, Deborah D, Nix, W. Allan, Oberste, M. Steven, Weldon, William C
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Neutralizing - analysis
Antibody titers
Capsid - immunology
Disease Outbreaks
Enterovirus
Enterovirus D, Human - immunology
Enterovirus D68
Enterovirus Infections - therapy
Humans
Immunoglobulins, Intravenous - administration & dosage
Immunoglobulins, Intravenous - analysis
Immunologic Factors - administration & dosage
Immunologic Factors - analysis
Infectious Disease
Intravenous immunoglobulin
United States - epidemiology
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Summary:Highlights • Developed an Enterovirus D68 (EV-D68)-specific microneutralization assay. • Detected high neutralizing antibody titers in intravenous immune globulin products. • Alignment of proposed antigenic sites may explain differences in titers. • Suggests possible effective treatment for primary antibody-deficient patients.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2015.06.086