Retrospective comparison of standard clotting tests and novel clot waveform parameters in dogs using the turbidimetric ACL-TOP CTS 300 coagulation analyzer

Clot waveforms are generated by coagulation analyzers, such as the ACL-TOP, that utilize photo-optical turbidimetric methods to measure prothrombin time (PT) and activated partial thromboplastin time (aPTT), which are standard clotting tests (SCTs). Additional quantitative clot waveform analysis (CW...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2018-11, Vol.30 (6), p.868-877
Main Authors: Yagneswar, Hamsini, Todd, Jeffrey M., Sharkey, Leslie C., Rendahl, Aaron, Tart, Kelly
Format: Article
Language:English
Subjects:
Animals
Blood Coagulation
Blood Coagulation Tests - methods
Blood Coagulation Tests - veterinary
Dog Diseases - physiopathology
Dogs
Female
Full Scientific Reports
Hemorrhage - physiopathology
Hemorrhage - veterinary
Male
Nephelometry and Turbidimetry - methods
Nephelometry and Turbidimetry - veterinary
Retrospective Studies
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Summary:Clot waveforms are generated by coagulation analyzers, such as the ACL-TOP, that utilize photo-optical turbidimetric methods to measure prothrombin time (PT) and activated partial thromboplastin time (aPTT), which are standard clotting tests (SCTs). Additional quantitative clot waveform analysis (CWA) parameters include maximum velocity of the PT curve (PT1d), maximum acceleration of the aPTT curve (aPTT2d), and their change in optical density (ODdelta). We explored the potential for CWA to contribute unique information compared to SCTs and quantitative fibrinogen assay (QFA) in dogs with clinical indications for laboratory evaluation of coagulation. We retrospectively evaluated the frequency and agreement between normal, high, and low values of CWA and SCTs for 203 dogs relative to reference intervals (RIs). Most dogs had SCTs within RIs, but most CWA values were high regardless of whether SCT values were within, below, or above the RI. Agreement between SCTs and CWA was slight (kappa
ISSN:1040-6387
1943-4936
DOI:10.1177/1040638718797386