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Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk
Purpose The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent. By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer e...
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Published in: | European journal of nutrition 2019-04, Vol.58 (3), p.1033-1045 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Purpose
The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent. By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer etiology.
Methods
The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55–69 years. At baseline, a random subcohort of 2589 women was sampled from the total cohort for a case–cohort analysis approach. Dietary acrylamide intake of subcohort members (
n
= 1449) and ER+ breast cancer cases (
n
= 844) was assessed with a food frequency questionnaire. We genotyped single nucleotide polymorphisms (SNPs) in genes in acrylamide metabolism, sex steroid systems, oxidative stress and DNA repair. Multiplicative interaction between acrylamide intake and SNPs was assessed with Cox proportional hazards analysis, based on 20.3 years of follow-up.
Results
Unexpectedly, there was a statistically non-significant inverse association between acrylamide and ER+ breast cancer risk among all women but with no clear dose–response relationship, and no association among never smokers. Among the results for 57 SNPs and 2 gene deletions, rs1056827 in
CYP1B1
, rs2959008 and rs7173655 in
CYP11A1
, the
GSTT1
gene deletion, and rs1052133 in
hOGG1
showed a statistically significant interaction with acrylamide intake for ER+ breast cancer risk.
Conclusions
This study did not provide evidence for a positive association between acrylamide intake and ER+ breast cancer risk. If anything, acrylamide was associated with a decreased ER+ breast cancer risk. The interaction with SNPs in
CYP1B1
and
CYP11A1
suggests that acrylamide may influence ER+ breast cancer risk through sex hormone pathways. |
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ISSN: | 1436-6207 1436-6215 |
DOI: | 10.1007/s00394-018-1619-z |