Bruch's Membrane Thickness and Retinal Pigment Epithelium Cell Density in Experimental Axial Elongation

To assess anatomical changes in eyes with progressive myopia, we morphometrically examined the eyes of guinea pigs with lens-induced axial elongation. Starting at an age of 3-4 weeks, guinea pigs in the experimental group (n = 20 animals) developed unilateral lens-induced axial elongation by wearing...

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Bibliographic Details
Published in:Scientific reports 2019-04, Vol.9 (1), p.6621-6621, Article 6621
Main Authors: Dong, Li, Shi, Xu Han, Kang, Yi Kun, Wei, Wen Bin, Wang, Ya Xing, Xu, Xiao Lin, Gao, Fei, Jonas, Jost B
Format: Article
Language:English
Subjects:
Animals
Axial Length, Eye - pathology
Bruch Membrane - pathology
Cell density
Choroid - pathology
Elongation
Epithelium
Eye
Guinea Pigs
Myopia
Myopia, Degenerative - pathology
Retina
Retina - pathology
Retinal pigment epithelium
Retinal Pigment Epithelium - pathology
Sclera - pathology
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Description
Summary:To assess anatomical changes in eyes with progressive myopia, we morphometrically examined the eyes of guinea pigs with lens-induced axial elongation. Starting at an age of 3-4 weeks, guinea pigs in the experimental group (n = 20 animals) developed unilateral lens-induced axial elongation by wearing goggles for 5 weeks compared to a control group of 20 animals without intervention (axial length:8.91 ± 0.08 mm versus 8.74 ± 0.07 mm; P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-43212-8