White matter – emotion processing activity relationships in youth offspring of bipolar parents

•We examined white matter and activity in youth at risk for Bipolar Disorder.•Forceps minor-anterior cingulate relationships distinguished bipolar offspring.•Relationships were inverse for bipolar offspring, positive for control offspring.•Group differences in relationships remained significant in u...

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Bibliographic Details
Published in:Journal of affective disorders 2019-01, Vol.243, p.153-164
Main Authors: Acuff, Heather E., Versace, Amelia, Bertocci, Michele A., Hanford, Lindsay C., Ladouceur, Cecile D., Manelis, Anna, Monk, Kelly, Bonar, Lisa, McCaffrey, Alicia, Goldstein, Benjamin I., Goldstein, Tina R., Sakolsky, Dara, Axelson, David, Birmaher, Boris, Phillips, Mary L.
Format: Article
Language:English
Subjects:
Adolescent
Amygdala - pathology
Amygdala - physiopathology
Anisotropy
Bipolar Disorder
Case-Control Studies
Child
Child of Impaired Parents - psychology
Diffusion Tensor Imaging
Emotions - physiology
Facial Expression
Female
Frontal Lobe - pathology
Frontal Lobe - physiopathology
Gyrus Cinguli - pathology
Gyrus Cinguli - physiopathology
Humans
Magnetic Resonance Imaging
Male
Parents - psychology
Prefrontal Cortex - pathology
Prefrontal Cortex - physiopathology
White Matter - pathology
White Matter - physiopathology
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Summary:•We examined white matter and activity in youth at risk for Bipolar Disorder.•Forceps minor-anterior cingulate relationships distinguished bipolar offspring.•Relationships were inverse for bipolar offspring, positive for control offspring.•Group differences in relationships remained significant in unmedicated youth.•Forceps minor-anterior cingulate relationships may indicate Bipolar Disorder risk. Early detection of Bipolar Disorder (BD) is critical for targeting interventions to delay or prevent illness onset. Yet, the absence of objective BD biomarkers makes accurately identifying at-risk youth difficult. In this study, we examined how relationships between white matter tract (WMT) structure and activity in emotion processing neural circuitry differentiate youth at risk for BD from youth at risk for other psychiatric disorders. Offspring (ages 8–17) of parents with BD (OBP, n = 32), offspring of comparison parents with non-BD psychopathology (OCP, n = 30), and offspring of healthy parents (OHP, n = 24) underwent diffusion tensor and functional magnetic resonance imaging while performing an emotional face processing task. Penalized and multiple regression analyses included GROUP(OBP,OCP)xWMT interactions as main independent variables, and emotion processing activity as dependent variables, to determine significant group differences in WMT-activity relationships. 8 GROUPxWMT interaction variables contributed to 16.5% of the variance in amygdala and prefrontal cortical activity to happy faces. Of these, significant group differences in slopes (inverse for OBP, positive for OCP) existed for the relationship between forceps minor radial diffusivity and rostral anterior cingulate activity (p = 0.014). Slopes remained significantly different in unmedicated youth without psychiatric disorders (p = 0.017) and were moderated by affective lability symptoms (F(1,29) = 5.566, p = 0.036). Relatively small sample sizes were included. Forceps minor radial diffusivity-rostral anterior cingulate activity relationships may reflect underlying neuropathological processes that contribute to affectively labile youth at risk for BD and may help differentiate them from youth at risk for other psychiatric disorders.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2018.09.010