Corticosteroid Receptors in the Brain: Transcriptional Mechanisms for Specificity and Context-Dependent Effects

Corticosteroid hormones act in the brain to support adaptation to stress via binding to mineralocorticoid and glucocorticoid receptors (MR and GR). These receptors act in large measure as transcription factors. Corticosteroid effects can be highly divergent, depending on the receptor type, but also...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2019-05, Vol.39 (4), p.539-549
Main Authors: Meijer, Onno C., Buurstede, J. C., Schaaf, Marcel J. M.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Corticosteroid receptors
Corticosteroids
Glucocorticoid receptors
Neurobiology
Neurosciences
Nuclear transport
Review Paper
Transcription factors
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Summary:Corticosteroid hormones act in the brain to support adaptation to stress via binding to mineralocorticoid and glucocorticoid receptors (MR and GR). These receptors act in large measure as transcription factors. Corticosteroid effects can be highly divergent, depending on the receptor type, but also on brain region, cell type, and physiological context. These differences ultimately depend on differential interactions of MR and GR with other proteins, which determine ligand binding, nuclear translocation, and transcriptional activities. In this review, we discuss established and potential mechanisms that confer receptor and cell type-specific effects of the MR and GR-mediated transcriptional effects in the brain.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-018-0625-2