Low fibrosis biomarker levels predict cardiac resynchronization therapy response

Cardiac fibrosis is associated with heart failure and poor prognosis. Fibrosis biomarkers have been poorly evaluated as a tool to predict cardiac resynchronization therapy (CRT) response generating conflicting results. The present study assessed the predictive value of cardiac fibrosis biomarkers on...

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Published in:Scientific reports 2019-04, Vol.9 (1), p.6103-6103, Article 6103
Main Authors: Massoullié, Grégoire, Sapin, Vincent, Ploux, Sylvain, Rossignol, Patrick, Mulliez, Aurélien, Jean, Frédéric, Marie, Pierre-Yves, Merlin, Charles, Pereira, Bruno, Andronache, Marius, Motreff, Pascal, Chabin, Xavier, Sellal, Jean-Marc, Citron, Bernard, Lusson, Jean-René, Vorilhon, Charles, Clerfond, Guillaume, Bordachar, Pierre, Zannad, Faiez, Eschalier, Romain
Format: Article
Language:English
Subjects:
Aged
Biomarkers
Biomarkers - blood
Cardiac Resynchronization Therapy
Cardiology and cardiovascular system
Cardiomyopathy
Congestive heart failure
Echocardiography
Female
Fibrosis
Heart failure
Heart Failure - pathology
Heart Failure - therapy
Human health and pathology
Humans
Ischemia
Life Sciences
Male
Middle Aged
Multivariate analysis
Peptide Fragments - blood
Procollagen
Procollagen - blood
Prospective Studies
Treatment Outcome
Ventricle
Ventricular Remodeling
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Summary:Cardiac fibrosis is associated with heart failure and poor prognosis. Fibrosis biomarkers have been poorly evaluated as a tool to predict cardiac resynchronization therapy (CRT) response generating conflicting results. The present study assessed the predictive value of cardiac fibrosis biomarkers on CRT response. Patients underwent clinical examination, echocardiography and blood fibrosis biomarker evaluation prior to CRT implantation. At six months, a positive response to CRT was defined by a composite endpoint of no death or hospitalization for heart failure, and presence of left ventricular (LV) reverse remodeling (decrease in LV end-systolic volume ≥15%). Sixty patients were included in a multicenter study. At 6 months, 38 were positive responders to CRT and reached the response criteria (63%). Compared to non-responders, CRT responders displayed lower concentration levels of the fibrosis biomarkers procollagen type I C-terminal propeptide [PICP 135[99-166] ng/ml vs. 179[142-226]ng/ml, p = 0.001)] and procollagen type III N-terminal propeptide [PIIINP 5.50[3.66-8.96] ng/ml vs. 8.01[5.01-11.86]ng/ml, p = 0.014)] at baseline. In multivariate analysis, a PICP ≤ 163 ng/ml was associated with a positive CRT response [OR = 7.8(1.3-46.7), p = 0.023] independently of the presence of LBBB, QRS duration, LV lead position or non-ischemic cardiomyopathy. Altogether, the present findings show that a lower degree of cardiac fibrosis is associated with a positive response after CRT implantation. PICP evaluation before CRT implantation could help improve patient selection.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-42468-4