T8. ATHEROGENIC LIPID RATIOS RELATED TO MYELOPEROXIDASE AND C-REACTIVE PROTEIN LEVELS IN PSYCHOTIC DISORDERS

Abstract Background Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders. The interaction between lipid accumulation, inflammation and vascular remodeling promotes atherogenesis and adverse CVD outcomes. We hypothesize that inflammatory markers reflec...

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Published in:Schizophrenia bulletin 2019-04, Vol.45 (Supplement_2), p.S206-S206
Main Authors: Reponen, Elina, Dieset, Ingrid, Tesli, Martin, Mørch, Ragni H, Steen, Nils Eiel, Hope, Sigrun, Vedal, Trude S J, Aas, Monica, Szabo, Attila, Gohar, Sherif M, Wedervang-Resell, Kirsten, Melle, Ingrid, Aukrust, Pål, Andreassen, Ole A, Ueland, Thor
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Language:English
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Poster Session I
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Summary:Abstract Background Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders. The interaction between lipid accumulation, inflammation and vascular remodeling promotes atherogenesis and adverse CVD outcomes. We hypothesize that inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis are associated with CVD risk in patients with psychotic disorders. Here we investigate general and stable down-stream markers of inflammation (high-sensitivity C-reactive protein, hs-CRP; glycoprotein 130, gp130), vascular inflammation, calcification, and endothelial function (pentraxin 3, PTX3; osteoprotegerin, OPG; von Willebrand factor, vWF;), markers related to fibrosis and extra-cellular matrix remodeling (galectin-3. Gal3; cathepsin S, CatS), neutrophil activation and function (myeloperoxidase, MPO), and vascular apoptosis (insulin-like growth factor-binding protein 4, IGFBP4). Methods We included 527 patients with schizophrenia spectrum disorders (SCZ), 288 patients with bipolar spectrum disorders (BD), and 95 healthy controls (HC). We measured fasting plasma levels of hs-CRP, PTX3, OPG, vWF, gp130, Gal3, CatS, MPO, and IGFBP4 in patients with psychotic disorders and HC. Differences between groups were analyzed by multivariate analysis of covariance adjusting for age, sex, and BMI. Cardio-metabolic risk was estimated using established atherogenic lipid ratios including total cholesterol/high-density lipoprotein-c (TC/HDL) and triglyceride/HDL (TG/HDL) using sex-dependent cut-offs, and differences in the proportion of individuals at risk between diagnostic groups was assessed using chi-square. Finally, in inflammatory markers that were elevated in patients (hs-CRP and MPO), the unadjusted and multivariable adjusted estimated atherogenic risk (i.e. based on lipid ratios) within the total patient population, and within diagnostic groups, was assessed using logistic regression, adjusting for age, sex, BMI, insulin resistance, smoking, systolic blood pressure and anti-psychotic treatment (defined daily dose; DDD). Results The patient group as a whole had a markedly higher proportion with enhanced TC/HDL (26.2%) and TG/HDL (30.5%) compared to HC (9.2% and 8.2% for TC/HDL and TG/HDL, respectively). The adjusted risk for an elevated TC/HDL was 2.69 [CI 1.29–5.60] and for an elevated TG/HDL was 3.16 [CI 1.47–6.80]. SCZ and BD groups were characterized by markedly higher MPO compared with HC, and
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/sbz019.288