Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors

Purpose The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [ 11 C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor. Methods High resolution [ 11 C]ABP688 P...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2019-05, Vol.46 (5), p.1179-1183
Main Authors: Smart, Kelly, Cox, Sylvia M. L., Scala, Stephanie G., Tippler, Maria, Jaworska, Natalia, Boivin, Michel, Séguin, Jean R., Benkelfat, Chawki, Leyton, Marco
Format: Article
Language:English
Subjects:
Adults
Binding
Brain
Brain - diagnostic imaging
Brain - metabolism
Carbon Radioisotopes
Cardiology
Cerebellum
Cognitive ability
Emission analysis
Female
Gender aspects
Gender differences
Glutamic acid receptors (metabotropic)
Healthy Volunteers
Humans
Imaging
Male
Medicine
Medicine & Public Health
Men
Menstrual cycle
Mental disorders
Neostriatum
Nuclear Medicine
Oncology
Orthopedics
Oximes - metabolism
Positron emission
Positron emission tomography
Prefrontal cortex
Protein Binding
Pyridines - metabolism
Radiology
Receptor, Metabotropic Glutamate 5 - metabolism
Receptors
Sex
Sex Characteristics
Sex differences
Short Communication
Substantia grisea
Tomography
Young Adult
Young adults
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Summary:Purpose The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [ 11 C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor. Methods High resolution [ 11 C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Mean binding potential (BP ND  =  f ND * (B avail / K D )) values were calculated in the prefrontal cortex, striatum, and limbic regions using the simplified reference tissue model with cerebellar grey matter as the reference region. Results [ 11 C]ABP688 BP ND was significantly higher in men compared to women in the prefrontal cortex ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-018-4252-4