The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus...

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Bibliographic Details
Published in:Journal of Neural Transmission 2019-03, Vol.126 (3), p.349-355
Main Authors: Pałasz, Artur, Bogus, Katarzyna, Suszka-Świtek, Aleksandra, Kaśkosz, Andrzej, Saint-Remy, Shirley, Piwowarczyk-Nowak, Aneta, Filipczyk, Łukasz, Worthington, John J., Mordecka-Chamera, Kinga, Kostro, Karol, Bajor, Grzegorz, Wiaderkiewicz, Ryszard
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Neurology
Neurosciences
Psychiatry
Psychiatry and Preclinical Psychiatric Studies - Short communication
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Summary:Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Nesfatin-1-expressing neurons were identified for the first time in several regions of the BNST using both immunohistochemical and fluorescent methods. This may implicate a potential contribution of this neuropeptide to the BNST-related mechanisms of stress/reward responses in the human brain.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-019-01984-3