Mitochondrial permeability transition pore: a potential drug target for neurodegeneration

•Mitochondrial permeability transition pore (mPTP) has been considered as a key cell death inducing process in several neurodegenerative diseases.•Studies suggest that mPTP inhibition can lead to promising therapeutics against neurodegenerative diseases.•Major bioactive entities can potentiate their...

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Bibliographic Details
Published in:Drug discovery today 2018-12, Vol.23 (12), p.1983-1989
Main Authors: Kalani, Komal, Yan, Shi Fang, Yan, Shirley ShiDu
Format: Article
Language:English
Subjects:
Animals
Cell Death - drug effects
Humans
Mitochondrial Membrane Transport Proteins - metabolism
Mitochondrial Permeability Transition Pore
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - metabolism
Small Molecule Libraries - pharmacology
Small Molecule Libraries - therapeutic use
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Summary:•Mitochondrial permeability transition pore (mPTP) has been considered as a key cell death inducing process in several neurodegenerative diseases.•Studies suggest that mPTP inhibition can lead to promising therapeutics against neurodegenerative diseases.•Major bioactive entities can potentiate their use against different neurodegenerative diseases which could benefice mPTP-based research using in silico approaches. The mitochondrial permeability transition pore (mPTP) has been considered a key contributor to cell death, inducing the process in several major neurodegenerative diseases. To date, the molecular nature of the mPTP remains confounding but its significance is universally acknowledged. Several targets have been screened and inhibition of mPTP has emerged as an attractive field for researchers. Nowadays, in silico-directed studies help to explore new small molecules targeting the mPTP to improve their drug-like properties and bioactivity. Here, we briefly summarize the role of mPTP in neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson disease (PD), and Huntington’s disease (HD), and discusses current and future potential therapeutic targets.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2018.08.001