Clinicopathological spectrum of xanthogranulomatous pyelonephritis

Xanthogranulomatous pyelonephritis (XGP) is an uncommon and distinct type of chronic infective pyelonephritis causing destruction of the kidney, severely affecting the renal function. The perinephric adipose tissue and peritoneum is not uncommonly involved. The study was undertaken to decipher the c...

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Bibliographic Details
Published in:Indian journal of nephrology 2019-03, Vol.29 (2), p.111-115
Main Authors: Kundu, R, Baliyan, A, Dhingra, H, Bhalla, V, Punia, R
Format: Article
Language:English
Subjects:
Adipose tissue
Antigens
Care and treatment
CAT scans
Cytoplasm
Diagnosis
Females
Histochemistry
Kidney diseases
Lipids
Nephrectomy
Neutrophils
Original
Pyelonephritis
Tumors
Ultrasonic imaging
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Summary:Xanthogranulomatous pyelonephritis (XGP) is an uncommon and distinct type of chronic infective pyelonephritis causing destruction of the kidney, severely affecting the renal function. The perinephric adipose tissue and peritoneum is not uncommonly involved. The study was undertaken to decipher the clinicopathologic spectrum of XGP. Forty cases of XGP were diagnosed on histopathology over a period of 13 years (2005-2017). Relevant clinical details and radiological findings were recorded from the case files. Out of a total of 40 cases, 26 were female and 14 were male with a mean age of 39.5 ± 13.6 years. Flank pain was the most common presenting symptom. All the patients had unilateral disease and underwent nephrectomy for a nonfunctional kidney. Gross examination showed enlarged kidney with replacement of cortico-medullary tissue by yellow nodular areas of fatty tissue and dilatation of the pelvicalyceal system. Thirty-six (90%) cases had nephrolithiasis. Histologically, the characteristic feature was the existence of lipid-laden foamy macrophages. Renal parenchymal involvement was diffuse in majority (31, 77.5%). Two (5.0%) of the patients had coexisting carcinoma in the same kidney. Histopathologic examination gives the definitive diagnosis of XGP which relies on the characteristic morphology. Surgical intervention in the form of nephrectomy is the treatment of choice and offers good treatment outcomes.
ISSN:0971-4065
1998-3662
DOI:10.4103/ijn.IJN_50_18